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https://hdl.handle.net/1822/80329
Título: | Pharmacological and non-pharmacological agents versus bovine colostrum supplementation for the management of bone health using an osteoporosis-induced rat model |
Autor(es): | Kydonaki, Eirini K. Freitas, Laura Reguengo, Henrique Simón, Carlos Raposo Bastos, Ana Raquel Fernandes Fernandes, Emanuel Mouta Canadas, Raphaël F. Oliveira, Joaquim M. Correlo, V. M. Reis, R. L. Vliora, Maria Gkiata, Paraskevi Koutedakis, Yiannis Ntina, Georgia Pinto, Rui Carrillo, Andres E. Marques, Franklim Amorim, Tânia |
Palavras-chave: | osteoporosis alessndronate vitamin D calcium bovine colostrum |
Data: | 11-Jul-2022 |
Editora: | Multidisciplinary Digital Publishing Institute |
Revista: | Nutrients |
Citação: | Kydonaki, E.K.; Freitas, L.; Reguengo, H.; Simón, C.R.; Bastos, A.R.; Fernandes, E.M.; Canadas, R.F.; Oliveira, J.M.; Correlo, V.M.; Reis, R.L.; Vliora, M.; Gkiata, P.; Koutedakis, Y.; Ntina, G.; Pinto, R.; Carrillo, A.E.; Marques, F.; Amorim, T. Pharmacological and Non-Pharmacological Agents versus Bovine Colostrum Supplementation for the Management of Bone Health Using an Osteoporosis-Induced Rat Model. Nutrients 2022, 14, 2837. https://doi.org/10.3390/nu14142837 |
Resumo(s): | Osteoporosis is defined by loss of bone mass and deteriorated bone microarchitecture. The present study compared the effects of available pharmacological and non-pharmacological agents for osteoporosis [alendronate (ALE) and concomitant supplementation of vitamin D (VD) and calcium (Ca)] with the effects of bovine colostrum (BC) supplementation in ovariectomized (OVX) and orchidectomized (ORX) rats. Seven-month-old rats were randomly allocated to: (1) placebo-control, (2) ALE group (7.5 μg/kg of body weight/day/5 times per week), (3) VD/Ca group (VD: 35 μg/kg of body weight/day/5 times per week; Ca: 13 mg/kg of body weight/day/3 times per week), and (4) BC supplementation (OVX: 1.5 g/day/5 times per week; ORX: 2 g/day/5 times per week). Following four months of supplementation, bone microarchitecture, strength and bone markers were evaluated. ALE group demonstrated significantly higher Ct.OV, Ct.BMC, Tb.Th, Tb.OV and Tb.BMC and significantly lower Ct.Pr, Tb.Pr, Tb.Sp, Ct.BMD and Tb.BMD, compared to placebo (<i>p</i> < 0.05). BC presented significantly higher Ct.Pr, Ct.BMD, Tb.Pr, Tb.Sp, and Tb.BMD and significantly lower Ct.OV, Ct.BMC, Tb.Th, Tb.OV and Tb.BMC compared to ALE in OVX rats (<i>p</i> < 0.05). OVX rats receiving BC experienced a significant increase in serum ALP and OC levels post-supplementation (<i>p</i> < 0.05). BC supplementation may induce positive effects on bone metabolism by stimulating bone formation, but appear not to be as effective as ALE. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/80329 |
DOI: | 10.3390/nu14142837 |
e-ISSN: | 2072-6643 |
Versão da editora: | https://www.mdpi.com/2072-6643/14/14/2837 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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nutrients-14-02837.pdf | 619,36 kB | Adobe PDF | Ver/Abrir |