Development of morphogen gradient: The role of dimension and discreteness

Date
2014
Journal Title
Journal ISSN
Volume Title
Publisher
AIP Publishing
Description
Abstract

The fundamental processes of biological development are governed by multiple signaling molecules that create non-uniform concentration profiles known as morphogen gradients. It is widely believed that the establishment of morphogen gradients is a result of complex processes that involve diffusion and degradation of locally produced signaling molecules. We developed a multi-dimensional discrete-state stochastic approach for investigating the corresponding reaction-diffusion models. It provided a full analytical description for stationary profiles and for important dynamic properties such as local accumulation times, variances, and mean first-passage times. The role of discreteness in developing of morphogen gradients is analyzed by comparing with available continuum descriptions. It is found that the continuum models prediction about multiple time scales near the source region in two-dimensional and three-dimensional systems is not supported in our analysis. Using ideas that view the degradation process as an effective potential, the effect of dimensionality on establishment of morphogen gradients is also discussed. In addition, we investigated how these reaction-diffusion processes are modified with changing the size of the source region.

Description
Advisor
Degree
Type
Journal article
Keywords
Citation

Teimouri, Hamid and Kolomeisky, Anatoly B.. "Development of morphogen gradient: The role of dimension and discreteness." The Journal of Chemical Physics, 140, no. 8 (2014) AIP Publishing: http://dx.doi.org/10.1063/1.4866453.

Has part(s)
Forms part of
Rights
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Link to license
Citable link to this page