Please use this identifier to cite or link to this item:
https://hdl.handle.net/1959.11/3489
Title: | Echinacea intake induces an immune response through altered expression of leucocyte hsp70, increased white cell counts and improved erythrocyte antioxidant defences |
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Contributor(s): | Agnew, Linda (author)![]() |
Publication Date: | 2005 |
DOI: | 10.1111/j.1365-2710.2005.00658.x |
Handle Link: | https://hdl.handle.net/1959.11/3489 |
Abstract: | Objective: To study the effect of Echinacea tablets on the expression of leucocyte heat shock protein 70 (hsp70), erythrocyte haemolysis, plasma antioxidant status, serum chemistry, haematological values and plasma alkylamide concentrations. Method: Eleven healthy individuals (26–61 years of age) were evaluated at baseline (day 1) and on day 15 after consuming two commercially blended Echinacea tablets daily for 14 days. Results: Echinacea supplementation enhanced the fold increase in leucocyte hsp70 expression after a mild heat shock (P = 0·029). White cell counts (WCC) were also increased (P = 0·043). We also observed a preventative effect against free radical induced erythrocyte haemolysis (P = 0·006) indicative of an antioxidant effect. Conclusion: The pilot study suggests that Echinacea may invoke an immune response through altered expression of hsp70 and increased WCC. |
Publication Type: | Journal Article |
Source of Publication: | Journal of Clinical Pharmacy and Therapeutics, 30(4), p. 363-369 |
Publisher: | Blackwell Publishing Ltd |
Place of Publication: | United Kingdom |
ISSN: | 0269-4727 |
Fields of Research (FoR) 2008: | 110203 Respiratory Diseases |
Socio-Economic Objective (SEO) 2008: | 920412 Preventive Medicine |
Peer Reviewed: | Yes |
HERDC Category Description: | C1 Refereed Article in a Scholarly Journal |
Appears in Collections: | Journal Article |
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