Lack of impact of protease inhibitor resistance-associated mutations on the outcome of HIV-1-infected patients switching to darunavir-based dual therapy.

Vizcarra, Pilar; Blanco, José L; Montejano, Rocío; Negredo, Eugenia; Espinosa, Nuria; Casado, José L; BIRDi study group

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Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/57708

Title:	Lack of impact of protease inhibitor resistance-associated mutations on the outcome of HIV-1-infected patients switching to darunavir-based dual therapy.
Authors:	Vizcarra, Pilar Blanco, José L Montejano, Rocío Negredo, Eugenia Espinosa, Nuria Casado, José L BIRDi study group View more
Keywords:	Dual therapy darunavir raltegravir resistance simplification switching View more
Mesh:	Adult Aged CD4-CD8 Ratio Cobicistat Darunavir Drug Combinations Drug Resistance, Viral Drug Substitution Drug Therapy, Combination Female Genotype HIV Infections HIV Integrase Inhibitors HIV Protease Inhibitors HIV-1 Humans Male Microbial Sensitivity Tests Middle Aged Mutation Raltegravir Potassium Retrospective Studies Ritonavir Sustained Virologic Response Time Factors Treatment Failure Young Adult View more
Issue Date:	25-Nov-2019
Citation:	Infect Dis (Lond).2020;(52)3:202-206
Abstract:	Background: Little is known about the impact of baseline resistance-associated mutations (RAMs) on the outcomes of alternative therapeutic strategies such as dual regimens. We assessed the efficacy of boosted darunavir plus raltegravir (DRV + RAL) dual regimen as a simplification strategy in virologically suppressed patients with protease inhibitors RAMs.Methods: Retrospective, multicentre study on the evolution of 228 heavily pretreated patients who switched to boosted DRV + RAL according to genotypic sensitivity score (GSS). Patients were classified as full susceptible (GSS = 2; n = 177), or with reduced darunavir susceptibility (GSS
PMID:	31760833
URI:	https://hdl.handle.net/20.500.12530/57708
Appears in Collections:	Fundaciones e Institutos de Investigación > IIS H. General U. Gregorio Marañón > Artículos Hospitales > H. U. Puerta de Hierro Majadahonda > Artículos Hospitales > H. U. Clínico San Carlos > Artículos Hospitales > H. U. Gregorio Marañón > Artículos Fundaciones e Institutos de Investigación > IIS H. U. La Paz > Artículos Fundaciones e Institutos de Investigación > IIS H. U. Clínico San Carlos > Artículos Fundaciones e Institutos de Investigación > IIS H. U. Ramón y Cajal > Artículos Fundaciones e Institutos de Investigación > IIS H. U. Puerta de Hierro-Segovia de Arana > Artículos Hospitales > H. U. Ramón y Cajal > Artículos

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