Chemical conditions; Gel swelling; Micro resonators; Microbubble resonators; Microbubbles; Optical-; Poly (vinyl alcohol) (PVA); Poly(vinyl alcohol); Poly(vinyl alcohol) (PVA); PVA-gel; Electronic, Optical and Magnetic Materials; Atomic and Molecular Physics, and Optics; Biomaterials; Radiology, Nuclear Medicine and Imaging
Abstract :
[en] A pH sensor can help understand chemical conditions of solutions, such as precise cell culture medium monitoring in real time. High-quality whispering-gallery-mode (WGM) microresonators have been utilized for surface sensing and are mainly based on the tracking of refractive index changes occurring within a wavelength range from their wall surface. This high sensitivity, reaching up to 10-5 RIU (∼2.5 nm/RIU and measured at a femtometer resolution) leads to a broad range of applications, especially for biosensing purposes through the monitoring of molecular binding events. Here, we study the deposition of thin layers of poly(vinyl alcohol)/poly(acrylic acid) (PVA/PAA) hydrogels inside a whispering gallery mode (WGM) microbubble resonator (MBR), fabricated inline with a silica capillary. The generation of such layers is achieved by withdrawing a liquid solution of 25% PVA/PAA in pure water into the MBR and locally heating the microbubble region, resulting in hydrogel formation only in the cavity. The capillary is then rinsed and tested with varying pH solutions. The swelling ability of these gels is directly proportional to the pH of samples brought into contact with the cavity, leading to physical modifications of the WGM coupling properties. We show the preliminary results obtained for the polymerization and characterization of these gels in microbubbles and present the related signal shifts observed for several pH values. We also discuss the gel kinetics over time and investigate practical uses such as reversible and tunable detection of small pH changes.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Loyez, Médéric ; Université de Mons - UMONS > Faculté des Sciences > Service de Protéomie et Microbiologie ; Washington University in St Louis > Electrical and Systems Engineering
Adolphson, Maxwell; Electrical and Systems Engineering, Washington University in St., Louis, United States
Liao, Jie; Electrical and Systems Engineering, Washington University in St., Louis, United States
Thakur, Sanskar; Electrical and Systems Engineering, Washington University in St., Louis, United States
Yang, Lan; Electrical and Systems Engineering, Washington University in St., Louis, United States
Language :
English
Title :
PH-sensitive optical micro-resonator based on PAA/PVA gel swelling
Publication date :
2023
Event name :
Optics and Biophotonics in Low-Resource Settings IX
Event organizer :
SPIE
Event place :
San Francisco, Usa
Event date :
28-01-2023 => 29-01-2023
Audience :
International
Main work title :
Optics and Biophotonics in Low-Resource Settings IX
Editor :
Levitz, David
Publisher :
SPIE
ISBN/EAN :
978-1-5106-5843-1
Peer reviewed :
Peer reviewed
Research unit :
Proteomics and Microbiology
Research institute :
Biosciences
Funders :
The Society of Photo-Optical Instrumentation Engineers (SPIE)
Yang, X., Ong, K. G., Dreschel, W. R., Zeng, K., Mungle, C. S. and Grimes, C. A., "Design of a wireless sensor network for long-Term, in-situ monitoring of an aqueous environment, " Sensors 2(11), 455 472 (2002).
Vivaldi, F., Bonini, A., Melai, B., Poma, N., Kirchhain, A., Santalucia, D., Salvo, P. and Francesco, F. Di., "A graphene-based pH sensor on paper for human plasma and seawater, " Proc. Annu. Int. Conf. IEEE Eng. Med. Biol. Soc. EMBS, 1563 1566 (2019).
Richter, A., Paschew, G., Klatt, S., Lienig, J., Arndt, K. F. and Adler, H. J. P., "Review on hydrogel-based pH sensors and microsensors, " Sensors 8(1), 561 581 (2008).
Zheng, Y., Dong, X., Ni, K., Chan, C. C. and Shum, P. P., "Miniature pH sensor based on optical fiber Fabry-Perot interferometer, " Proc. 2014 IEEE 7th Int. Conf. Adv. Infocomm Technol. IEEE/ICAIT 2014, 192 197 (2015).
Gerlach, G., Guenther, M., Suchaneck, G., Sorber, J., Arndt, K. F. and Richter, A., "Application of sensitive hydrogels in chemical and pH sensors, " Macromol. Symp. 210, 403 410 (2004).
Manavi-Tehrani, I., Rabiee, M., Parviz, M., Tahriri, M. R. and Fahimi, Z., "Preparation, characterization and controlled release investigation of biocompatible pH-sensitive PVA/PAA hydrogels, " Macromol. Symp. 296(1), 457 465 (2010).
Pabbisetti, V. N. K. and Madhuvarasu, S. S., "Hydrogel-coated fiber Bragg grating sensor for pH monitoring, " Opt. Eng. 55(6), 066112 (2016).
Shaibani, P. M., Jiang, K., Haghighat, G., Hassanpourfard, M., Etayash, H., Naicker, S. and Thundat, T., "The detection of Escherichia coli (E. coli) with the pH sensitive hydrogel nanofiber-light addressable potentiometric sensor (NF-LAPS), " Sensors Actuators, B Chem. 226, 176 183 (2016).
Toropov, N., Cabello, G., Serrano, M. P., Gutha, R. R., Rafti, M. and Vollmer, F., "Review of biosensing with whispering-gallery mode lasers, " Light Sci. Appl. 10(1) (2021).
Foreman, M. R., Swaim, J. D. and Vollmer, F., "Whispering gallery mode sensors, " Adv. Opt. Photonics 7(2), 168 240 (2015).
Jiang, X., Qavi, A. J., Huang, S. H. and Yang, L., "Whispering-Gallery Sensors, " Matter 3(2), 371 392 (2020).