Publication: Interacción y relevancia biológica de la lectina DC-SIGN con la envuelta del virus emergente SARS-CoV-2
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2023-06
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Universidad Complutense de Madrid
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Abstract
La lectina de tipo C DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin), también llamada CD209 o molécula de adhesión intracelular 3 no asociada a integrina (ICAM-3) específica de células dendríticas (DC), es una proteína transmembrana dependiente de Ca+ que reconoce estructuras con un alto contenido en manosa como las glicosilaciones presentes en los receptores de superficie de la envuelta de multitud de virus, mediante un dominio lectina C-terminal de reconocimiento de carbohidratos (CDR). El reconocimiento de DC-SIGN de patrones específicos de carbohidratos presentes en las envueltas víricas resulta de gran importancia para el estudio de los mecanismos de infección y diseminación viral de los mismos. DC-SIGN se expresa concretamente en células dendríticas inmaduras de tejidos periféricos y podemos localizarla en diversos lugares como amigadlas, tejidos mucosos, ganglios linfáticos y bazo. Las células dendríticas (DCs) forman parte de un sistema de vigilancia especializado contra las infecciones formado por las llamadas células presentadoras de antígeno (APC), las cuales resultan cruciales en el reconocimiento de antígenos ya que su funcionalidad determina el tipo de célula T efectora que mediará la respuesta inmune. Las DCs son una de las primeras líneas de defensa ante la invasión patógena siendo fundamentales en la regulación de la respuesta inmune capturando, procesando y presentando antígenos a linfocitos T para generar respuestas inmune específicas, es por ello por lo que las DCs actúan como nexo entre la inmunidad innata y adaptativa...
DC-SIGN type C lectin (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin), also known as CD209 or intracellular adhesion molecule 3 non associated to integrin (ICAM-3) specific to dendritic cells (DC), is a transmembrane protein dependent on Ca+ that recognizes structures with a high content of mannose, like glycosylations present in multitude of viral envelope surface receptors, through a C-terminal lectin carbohydrate domain recognition (CDR). Recognition of DC-SIGN carbohydrate specific patterns present in the viral envelopes is of great importance for the study of infection mechanisms and viral dissemination. DC-SIGN is revealed concretely in immature dendritic cells of peripheral tissues and we can locate it in various places like the tonsils, mucous tissues, lymph nodes, and the spleen. Dendritic cells (DCs) are part of a vigilance system specialized against infections, made up by the so-called antigen presenting cells (APC), which are crucial in the recognition of antigens due to its functionality defining the effector T cell type that will mediate the immune response. DCs are one of the main lines of defence against pathogen invasion, being essential in the regulation of the immune response by capturing, processing and presenting antigens to T lymphocytes to generate specific immune responses, it is because of this that DCs act as a nexus between innate and adaptative immunity...
DC-SIGN type C lectin (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin), also known as CD209 or intracellular adhesion molecule 3 non associated to integrin (ICAM-3) specific to dendritic cells (DC), is a transmembrane protein dependent on Ca+ that recognizes structures with a high content of mannose, like glycosylations present in multitude of viral envelope surface receptors, through a C-terminal lectin carbohydrate domain recognition (CDR). Recognition of DC-SIGN carbohydrate specific patterns present in the viral envelopes is of great importance for the study of infection mechanisms and viral dissemination. DC-SIGN is revealed concretely in immature dendritic cells of peripheral tissues and we can locate it in various places like the tonsils, mucous tissues, lymph nodes, and the spleen. Dendritic cells (DCs) are part of a vigilance system specialized against infections, made up by the so-called antigen presenting cells (APC), which are crucial in the recognition of antigens due to its functionality defining the effector T cell type that will mediate the immune response. DCs are one of the main lines of defence against pathogen invasion, being essential in the regulation of the immune response by capturing, processing and presenting antigens to T lymphocytes to generate specific immune responses, it is because of this that DCs act as a nexus between innate and adaptative immunity...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias Biológicas, leída el 06/03/2023.