Sequence and functional expression of the GABAA receptor shows a ligand-gated 
receptor super-family

Schofield, Peter R.; Darlison, Mark G.; Fujita, Norihisa; Rodriguez, Henry F.; Burt, David R.; Stephenson, Anne; Rhee, Lucy M.; Ramachandran, J.; Glencorse, Thora A.; Reale, Vincenzina; Seeburg, Peter H.; Barnard, Eric A.

doi:10.1038/328221a0

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

学術論文

Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family

MPS-Authors

/persons/resource/persons95292

Seeburg, Peter H.
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

External Resource

https://doi.org/10.1038/328221a0
(全文テキスト（全般）)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

公開されているフルテキストはありません

付随資料 (公開)

There is no public supplementary material available

引用

Schofield, P. R., Darlison, M. G., Fujita, N., Rodriguez, H. F., Burt, D. R., Stephenson, A., Rhee, L. M., Ramachandran, J., Glencorse, T. A., Reale, V., Seeburg, P. H., & Barnard, E. A. (1987). Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family. Nature, 328(6127), 221-227. doi:10.1038/328221a0.

引用: https://hdl.handle.net/21.11116/0000-0000-C8E9-8

要旨

Amino-acid sequences derived from complementary DNAs encoding the alpha- and beta-subunits of the GABA/benzodiazepine receptor from bovine brain show homology with other ligand-gated receptor subunits, suggesting that there is a super-family of ion-channel-containing receptors. Co-expression of the in vitro-generated alpha-subunit and beta-subunit RNAs in Xenopus oocytes produces a functional receptor and ion channel with the pharmacological properties characteristic of the GABAA receptor.