The C. elegans RSA complex localizes protein phosphatase 2A to centrosomes and 
regulates mitotic spindle assembly

Schlaitz, Anne-Lore; Srayko, Martin; Dammermann, Alexander; Quintin, Sophie; Wielsch, Natalie; MacLeod, Ian; Robillard, Quentin de; Zinke, Andrea; Yates, John R.; Muller-Reichert, Thomas; Shevchenko, Andrej; Oegema, Karen; Hyman, Anthony A.

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The C. elegans RSA complex localizes protein phosphatase 2A to centrosomes and regulates mitotic spindle assembly

MPS-Authors

/persons/resource/persons219630

Schlaitz, Anne-Lore
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219686

Srayko, Martin
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219557

Quintin, Sophie
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons16217

Wielsch, Natalie
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219812

Zinke, Andrea
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219471

Muller-Reichert, Thomas
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons218972

Shevchenko, Andrej
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219500

Oegema, Karen
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219253

Hyman, Anthony A.
Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society;

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引用

Schlaitz, A.-L., Srayko, M., Dammermann, A., Quintin, S., Wielsch, N., MacLeod, I., Robillard, Q. d., Zinke, A., Yates, J. R., Muller-Reichert, T., Shevchenko, A., Oegema, K., & Hyman, A. A. (2007). The C. elegans RSA complex localizes protein phosphatase 2A to centrosomes and regulates mitotic spindle assembly. Cell, 128(1), 115-127.

引用: https://hdl.handle.net/21.11116/0000-0001-0FAC-E

要旨

Microtubule behavior changes during the cell cycle and during spindle assembly. However, it remains unclear how these changes are regulated and coordinated. We describe a complex that targets the Protein Phosphatase 2A holoenzyme (PP2A) to centrosomes in C. elegans embryos. This complex includes Regulator of Spindle Assembly 1 (RSA-1), a targeting subunit for PP2A, and RSA-2, a protein that binds and recruits RSA-1 to centrosomes. In contrast to the multiple functions of the PP2A catalytic subunit, RSA-1 and RSA-2 are specifically required for microtubule outgrowth from centrosomes and for spindle assembly. The centrosomally localized RSA-PP2A complex mediates these functions in part by regulating two critical mitotic effectors: the microtubule destabilizer KLP-7 and the C. elegans regulator of spindle assembly TPXL-1. By regulating a subset of PP2A functions at the centrosome, the RSA complex could therefore provide a means of coordinating microtubule outgrowth from centrosomes and kinetochore microtubule stability during mitotic spindle assembly.