Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT

Freigegeben

Zeitschriftenartikel

Analysis of 3800-year-old Yersinia pestis genomes suggests Bronze Age origin for bubonic plague

MPG-Autoren
/persons/resource/persons189338

Spyrou,  Maria A.
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons202633

Wang,  Chuan-Chao
Eurasia3angle, Max Planck Institute for the Science of Human History, Max Planck Society;
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons203211

Andrades Valtueña,  Aida
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons217824

Lankapalli,  Aditya Kumar
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons221052

Kühnert,  Denise
tide, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons179620

Herbig,  Alexander
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons188392

Bos,  Kirsten I.
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons72801

Krause,  Johannes
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;
MHAAM, Max Planck Institute for the Science of Human History, Max Planck Society;

Externe Ressourcen
Es sind keine externen Ressourcen hinterlegt
Volltexte (beschränkter Zugriff)
Für Ihren IP-Bereich sind aktuell keine Volltexte freigegeben.
Volltexte (frei zugänglich)

shh1006.pdf
(Verlagsversion), 3MB

Ergänzendes Material (frei zugänglich)
Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar
Zitation

Spyrou, M. A., Tukhbatova, R. I., Wang, C.-C., Andrades Valtueña, A., Lankapalli, A. K., Kondrashin, V. V., et al. (2018). Analysis of 3800-year-old Yersinia pestis genomes suggests Bronze Age origin for bubonic plague. Nature Communications, 9: 2234. doi:10.1038/s41467-018-04550-9.


Zitierlink: https://hdl.handle.net/21.11116/0000-0001-7199-3
Zusammenfassung
The origin of Yersinia pestis and the early stages of its evolution are fundamental subjects of investigation given its high virulence and mortality that resulted from past pandemics. Although the earliest evidence of Y. pestis infections in humans has been identified in Late Neolithic/Bronze Age Eurasia (LNBA 5000–3500y BP), these strains lack key genetic components required for flea adaptation, thus making their mode of transmission and disease presentation in humans unclear. Here, we reconstruct ancient Y. pestis genomes from individuals associated with the Late Bronze Age period (~3800 BP) in the Samara region of modern-day Russia. We show clear distinctions between our new strains and the LNBA lineage, and suggest that the full ability for flea-mediated transmission causing bubonic plague evolved more than 1000 years earlier than previously suggested. Finally, we propose that several Y. pestis lineages were established during the Bronze Age, some of which persist to the present day.