Mathematical Modeling of the Neuronal Processes in Sugar Addiction

Almeida, A; Celaymanian, H; Seel, N; Zak, B; Noori, HR

doi:10.1038/npre.2011.5546.2

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Mathematical Modeling of the Neuronal Processes in Sugar Addiction

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Almeida, A., Celaymanian, H., Seel, N., Zak, B., & Noori, H. (2011). Mathematical Modeling of the Neuronal Processes in Sugar Addiction.

Cite as: https://hdl.handle.net/21.11116/0000-0001-BCA2-4

Abstract

It has already been demonstrated that the body responds to enhanced intake of sugar and is conducive to a natural form of addiction. There are substantial neurochemical changes in the brain (especially dopamine and acetylcholine systems) similar to other addictive drugs. A mathematical model comprised by a system of delayed leaky integrate-and-re equations is established to simulate the effects of sugar on a reward-circuitry. Simulations with Neuron suggest agreement with the neurobiological hypotheses of hyperactivity of neural systems due to binge sugar intake.