Efficacy of sterile fecal filtrate transfer for treating patients with 
Clostridium difficile infection

Ott, Stephan J.; Waetzig, Georg H.; Rehman, Ateequr; Moltzau-Anderson, Jacqueline; Bharti, Richa; Grasis, Juris A.; Cassidy, Liam; Tholey, Andreas; Fickenscher, Helmut; Seegert, Dirk; Rosenstiel, Philip; Schreiber, Stefan

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Efficacy of sterile fecal filtrate transfer for treating patients with Clostridium difficile infection

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Moltzau-Anderson, Jacqueline
Max Planck Institute for Evolutionary Biology, Max Planck Society;

Externe Ressourcen

https://www.gastrojournal.org/article/S0016-5085(16)35354-9/pdf
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PIIS0016508516353549.pdf
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Zitation

Ott, S. J., Waetzig, G. H., Rehman, A., Moltzau-Anderson, J., Bharti, R., Grasis, J. A., et al. (2017). Efficacy of sterile fecal filtrate transfer for treating patients with Clostridium difficile infection. Gastroenterology, 152(4), 799-811.e7. Retrieved from https://doi.org/10.1053/j.gastro.2016.11.010.

Zitierlink: https://hdl.handle.net/21.11116/0000-0002-F84B-3

Zusammenfassung

Background & AimsFecal microbiota transplantation (FMT) is a highly effective therapy for recurrent Clostridium difficile infection (CDI). However, transferring undefined living bacteria entails uncontrollable risks for infectious and metabolic or malignant diseases, particularly in immunocompromised patients. We investigated whether sterile fecal filtrates (containing bacterial debris, proteins, antimicrobial compounds, metabolic products, and oligonucleotides/DNA), rather than intact microorganisms, are effective in patients with CDI.