Gene-Mediated Chemical Communication in Synthetic Protocell Communities.

Tang, T-Y Dora; Cecchi, Dario; Fracasso, Giorgio; Accardi, Davide; Coutable-Pennarun, Angelique; Mansy, Sheref S; Perriman, Adam W; Anderson, J L Ross; Mann, Stephen

doi:10.1021/acssynbio.7b00306

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Gene-Mediated Chemical Communication in Synthetic Protocell Communities.

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Tang, T-Y Dora
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Fracasso, Giorgio
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Accardi, Davide
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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引用

Tang, T.-Y.-D., Cecchi, D., Fracasso, G., Accardi, D., Coutable-Pennarun, A., Mansy, S. S., Perriman, A. W., Anderson, J. L. R., & Mann, S. (2018). Gene-Mediated Chemical Communication in Synthetic Protocell Communities. ACS synthetic biology, 7(2), 339-346. doi:10.1021/acssynbio.7b00306.

引用: https://hdl.handle.net/21.11116/0000-0003-F69C-8

要旨

A gene-directed chemical communication pathway between synthetic protocell signaling transmitters (lipid vesicles) and receivers (proteinosomes) was designed, built and tested using a bottom-up modular approach comprising small molecule transcriptional control, cell-free gene expression, porin-directed efflux, substrate signaling, and enzyme cascade-mediated processing.