No robust differences in fear conditioning between patients with fear-related 
disorders and healthy controls

Pöhlchen, Dorothee; Leuchs, Laura; Binder, Florian P.; Blaskovich, Borbala; Nantawisarakul, Taechawidd; Topalidis, Pavlos; Brückl, Tanja M.; Norrholm, Seth D.; Jovanovic, Tanja; Spoormaker, Victor I.; Binder, Elisabeth B.; Czisch, Michael; Erhardt, Angelika; Grandi, Norma C.; Ilic-Cocic, Sanja; Lucae, Susanne; Saemann, Philipp; Tontsch, Alina

doi:10.1016/j.brat.2020.103610

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No robust differences in fear conditioning between patients with fear-related disorders and healthy controls

MPS-Authors

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Pöhlchen, Dorothee
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;
IMPRS Translational Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

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Leuchs, Laura
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

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Binder, Florian P.
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;
IMPRS Translational Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

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Blaskovich, Borbala
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons262567

Nantawisarakul, Taechawidd
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

Topalidis, Pavlos
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

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Brückl, Tanja M.
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80538

Spoormaker, Victor I.
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80272

Binder, Elisabeth B.
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80295

Czisch, Michael
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80316

Erhardt, Angelika
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons257167

Grandi, Norma C.
Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons262564

Ilic-Cocic, Sanja
Max Planck Institute of Psychiatry, Max Planck Society;

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Lucae, Susanne
Max Planck Institute of Psychiatry, Max Planck Society;

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Saemann, Philipp
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80555

Tontsch, Alina
Max Planck Institute of Psychiatry, Max Planck Society;

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引用

Pöhlchen, D., Leuchs, L., Binder, F. P., Blaskovich, B., Nantawisarakul, T., Topalidis, P., Brückl, T. M., Norrholm, S. D., Jovanovic, T., Spoormaker, V. I., Binder, E. B., Czisch, M., Erhardt, A., Grandi, N. C., Ilic-Cocic, S., Lucae, S., Saemann, P., & Tontsch, A. (2020). No robust differences in fear conditioning between patients with fear-related disorders and healthy controls. BEHAVIOUR RESEARCH AND THERAPY, 129:. doi:10.1016/j.brat.2020.103610.

引用: https://hdl.handle.net/21.11116/0000-0008-BC6C-C

要旨

Fear conditioning and extinction serve as a dominant model for the development and maintenance of pathological anxiety, particularly for phasic fear to specific stimuli or situations. The validity of this model would be supported by differences in the physiological or subjective fear response between patients with fear-related disorders and healthy controls, whereas the model's validity would be questioned by a lack of such differences.
We derived pupillometry, skin conductance response and startle electromyography as well as unconditioned stimulus expectancy in a two-day fear acquisition, immediate extinction and recall task and compared an unmedicated group of patients (n = 73) with phobias or panic disorder and a group of patients with posttraumatic stress disorder (PTSD, n = 21) to a group of carefully screened healthy controls (n = 35).
Bayesian statistics showed no convincing evidence for a difference in physiological and subjective responses between the groups during fear acquisition, extinction learning or recall. Only the PTSD subgroup had altered startle reactions during extinction learning.
Our data do not provide evidence for general differences in associative fear or extinction learning in fear-related pathologies and thereby question the diagnostic validity of the associative fear learning model of these disorders.