Human glioma-initiating cells show a distinct immature phenotype resembling but 
not identical to NG2 glia

Barrantes-Freer, A.; Kim, E.; Bielanska, J.; Giese, A.; Mortensen, L. S.; Schulz-Schaeffer, W. J.; Stadelmann, C.; Bruck, W.; Pardo, L. A.

doi:10.1097/NEN.0b013e31828afdbd

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学術論文

Human glioma-initiating cells show a distinct immature phenotype resembling but not identical to NG2 glia

MPS-Authors

Barrantes-Freer, A.
Max Planck Society;

Kim, E.
Max Planck Society;

Bielanska, J.
Max Planck Society;

Giese, A.
Max Planck Society;

Mortensen, L. S.
Max Planck Society;

Schulz-Schaeffer, W. J.
Max Planck Society;

Stadelmann, C.
Max Planck Society;

Bruck, W.
Max Planck Society;

Pardo, L. A.
Max Planck Society;

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引用

Barrantes-Freer, A., Kim, E., Bielanska, J., Giese, A., Mortensen, L. S., Schulz-Schaeffer, W. J., Stadelmann, C., Bruck, W., & Pardo, L. A. (2013). Human glioma-initiating cells show a distinct immature phenotype resembling but not identical to NG2 glia. J Neuropathol Exp Neurol, 72(4), 307-24. doi:10.1097/NEN.0b013e31828afdbd.

引用: https://hdl.handle.net/21.11116/0000-0009-F23F-0

要旨

Glioma-initiating cells (GICs) represent a potential important therapeutic target because they are likely to account for the frequent recurrence of malignant gliomas; however, their identity remains unsolved. Here, we characterized the cellular lineage fingerprint of GICs through a combination of electrophysiology, lineage marker expression, and differentiation assays of 5 human patient-derived primary GIC lines. Most GICs coexpressed nestin, NG2 proteoglycan, platelet-derived growth factor receptor-alpha, and glial fibrillary acidic protein. Glioma-initiating cells could be partially differentiated into astrocytic but not oligodendroglial or neural lineages. We also demonstrate that GICs have a characteristic electrophysiologic profile distinct from that of well-characterized tumor bulk cells. Together, our results suggest that GICs represent a unique type of cells reminiscent of an immature phenotype that closely resembles but is not identical to NG2 glia with respect to marker expression and functional membrane properties.