Dietary tryptophan links encephalogenicity of autoreactive T cells with gut 
microbial ecology

Sonner, Jana K.; Keil, Melanie; Falk-Paulsen, Maren; Mishra, Neha; Rehman, Ateequr; Kramer, Magdalena; Deumelandt, Katrin; Roewe, Julian; Sanghvi, Khwab; Wolf, Lara; von Landenberg, Anna; Wolff, Hendrik; Bharti, Richa; Oezen, Iris; Lanz V, Tobias; Wanke, Florian; Tang, Yilang; Brandao, Ines; Mohapatra, Soumya R.; Epping, Lisa; Grill, Alexandra; Roeth, Ralph; Niesler, Beate; Meuth, Sven G.; Opitz, Cristiane A.; Okun, Juergen G.; Reinhardt, Christoph; Kurschus, Florian C.; Wick, Wolfgang; Bode, Helge B.; Rosenstiel, Philip; Platten, Michael

doi:10.1038/s41467-019-12776-4

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

学術論文

Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology

MPS-Authors

There are no MPG-Authors in the publication available

External Resource

There are no locators available

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

公開されているフルテキストはありません

付随資料 (公開)

There is no public supplementary material available

引用

Sonner, J. K., Keil, M., Falk-Paulsen, M., Mishra, N., Rehman, A., Kramer, M., Deumelandt, K., Roewe, J., Sanghvi, K., Wolf, L., von Landenberg, A., Wolff, H., Bharti, R., Oezen, I., Lanz V, T., Wanke, F., Tang, Y., Brandao, I., Mohapatra, S. R., Epping, L., Grill, A., Roeth, R., Niesler, B., Meuth, S. G., Opitz, C. A., Okun, J. G., Reinhardt, C., Kurschus, F. C., Wick, W., Bode, H. B., Rosenstiel, P., & Platten, M. (2019). Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology. NATURE COMMUNICATIONS, 10:. doi:10.1038/s41467-019-12776-4.

引用: https://hdl.handle.net/21.11116/0000-000A-055A-C

要旨

The interaction between the mammalian host and its resident gut microbiota is known to license adaptive immune responses. Nutritional constituents strongly influence composition and functional properties of the intestinal microbial communities. Here, we report that omission of a single essential amino acid - tryptophan - from the diet abrogates CNS autoimmunity in a mouse model of multiple sclerosis. Dietary tryptophan restriction results in impaired encephalitogenic T cell responses and is accompanied by a mild intestinal inflammatory response and a profound phenotypic shift of gut microbiota. Protective effects of dietary tryptophan restriction are abrogated in germ-free mice, but are independent of canonical host sensors of intracellular tryptophan metabolites. We conclude that dietary tryptophan restriction alters metabolic properties of gut microbiota, which in turn have an impact on encephalitogenic T cell responses. This link between gut microbiota, dietary tryptophan and adaptive immunity may help to develop therapeutic strategies for protection from autoimmune neuroinflammation.