Small proteins modulate ion-channel-like ACD6 to regulate immunity in 
Arabidopsis thaliana

Chen, J; Li, L; Kim, JH; Neuhäuser, B; Wang, M; Thelen, M; Hilleary, R; Chi, Y; Wei, L; Venkataramani, K; Exposito-Alonso, M; Liu, C; Keck, J; Barragan, AC; Schwab, R; Lutz, U; Pei, Z-M; He, S-Y; Ludewig, U; Weigel, D; Zhu, W

doi:10.1016/j.molcel.2023.10.030

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Small proteins modulate ion-channel-like ACD6 to regulate immunity in Arabidopsis thaliana

MPG-Autoren

/persons/resource/persons272379

Li, L
Department Molecular Biology, Max Planck Institute for Biology Tübingen, Max Planck Society;

/persons/resource/persons274725

Thelen, M
Department Molecular Biology, Max Planck Institute for Biology Tübingen, Max Planck Society;

/persons/resource/persons274728

Venkataramani, K
Department Molecular Biology, Max Planck Institute for Biology Tübingen, Max Planck Society;

/persons/resource/persons273178

Exposito-Alonso, M
Department Molecular Biology, Max Planck Institute for Biology Tübingen, Max Planck Society;

/persons/resource/persons274732

Keck, J
Department Molecular Biology, Max Planck Institute for Biology Tübingen, Max Planck Society;

/persons/resource/persons272441

Barragan, AC
Department Molecular Biology, Max Planck Institute for Biology Tübingen, Max Planck Society;

/persons/resource/persons271416

Schwab, R
Department Molecular Biology, Max Planck Institute for Biology Tübingen, Max Planck Society;

/persons/resource/persons272299

Lutz, U
Department Molecular Biology, Max Planck Institute for Biology Tübingen, Max Planck Society;

/persons/resource/persons85266

Weigel, D
Department Molecular Biology, Max Planck Institute for Biology Tübingen, Max Planck Society;

/persons/resource/persons272318

Zhu, W
Department Molecular Biology, Max Planck Institute for Biology Tübingen, Max Planck Society;

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Zitation

Chen, J., Li, L., Kim, J., Neuhäuser, B., Wang, M., Thelen, M., et al. (2023). Small proteins modulate ion-channel-like ACD6 to regulate immunity in Arabidopsis thaliana. Molecular Cell, 83(23), 4386-4397. doi:10.1016/j.molcel.2023.10.030.

Zitierlink: https://hdl.handle.net/21.11116/0000-000D-F95F-1

Zusammenfassung

The multi-pass transmembrane protein ACCELERATED CELL DEATH 6 (ACD6) is an immune regulator in Arabidopsis thaliana with an unclear biochemical mode of action. We have identified two loci, MODULATOR OF HYPERACTIVE ACD6 1 (MHA1) and its paralog MHA1-LIKE (MHA1L), that code for ∼7 kDa proteins, which differentially interact with specific ACD6 variants. MHA1L enhances the accumulation of an ACD6 complex, thereby increasing the activity of the ACD6 standard allele for regulating plant growth and defenses. The intracellular ankyrin repeats of ACD6 are structurally similar to those found in mammalian ion channels. Several lines of evidence link increased ACD6 activity to enhanced calcium influx, with MHA1L as a direct regulator of ACD6, indicating that peptide-regulated ion channels are not restricted to animals.