A guideline on the molecular ecosystem regulating ferroptosis

Dai, Enyong; Chen, Xin; Linkermann, Andreas; Jiang, Xuejun; Kang, Rui; Kagan, Valerian E.; Bayir, Hülya; Yang, Wan Seok; Garcia-Saez, Ana J.; Garcia-Saez, Ana J.; Ioannou, Maria S.; Janowitz, Tobias; Ran, Qitao; Gu, Wei; Gan, Boyi; Krysko, Dmitri V.; Zhu, Xiaofeng; Wang, Jiayi; Krautwald, Stefan; Toyokuni, Shinya; Xie, Yangchun; Greten, Florian R.; Yi, Qing; Schick, Joel; Liu, Jiao; Gabrilovich, Dmitry I.; Liu, Jinbao; Zeh, Herbert J.; Zhang, Donna D.; Yang, Minghua; Iovanna, Juan; Kopf, Manfred; Adolph, Timon E.; Chi, Jen-Tsan; Li, Changfeng; Ichijo, Hidenori; Karin, Michael; Sankaran, Vijay G.; Zou, Weiping; Galluzzi, Lorenzo; Bush, Ashley I.; Li, Binghui; Melino, Gerry; Baehrecke, Eric H.; Lotze, Michael T.; Klionsky, Daniel J.; Stockwell, Brent R.; Kroemer, Guido; Tang, Daolin

doi:10.1038/s41556-024-01360-8

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

A guideline on the molecular ecosystem regulating ferroptosis

MPS-Authors

There are no MPG-Authors in the publication available

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Dai, E., Chen, X., Linkermann, A., Jiang, X., Kang, R., Kagan, V. E., et al. (2024). A guideline on the molecular ecosystem regulating ferroptosis. Nature Cell Biology. doi:10.1038/s41556-024-01360-8.

Cite as: https://hdl.handle.net/21.11116/0000-000E-8195-7

Abstract

Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mechanisms that govern ferroptosis induction and defence, with particular emphasis on the roles of heterogeneity and plasticity. In this Review, we discuss the molecular ecosystem of ferroptosis, with implications that may inform and enable safe and effective therapeutic strategies across a broad spectrum of diseases.