[en] Translocation t(2p;3q) is a rare but recurrent finding in myeloid disorders. We present the first case of primary myelofibrosis with t(2;3)(p21;q26) as the sole chromosomal anomaly. The comparison with the 11 other previously published myeloid-associated t(2p;3q) cases confirms that this nonrandom translocation involves a pluripotent stem cell and is associated with a poor prognosis.
Disciplines :
Hematology Genetics & genetic processes
Author, co-author :
Herens, Christian ; Centre Hospitalier Universitaire de Liège - CHU > Génétique
Hermanne, Jean-Philippe; Centre Hospitalier Universitaire de Liège - CHU
Tassin, Françoise ; Centre Hospitalier Universitaire de Liège - CHU > Hématologie biologique et immuno hématologie
Fassotte, Marie-France ; Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
Thiry, Albert ; Université de Liège - ULiège > Anatomie pathologique
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
Bibliography
Berger R., Flexor M., Le Coniat M., Derré J., Leblanc T. Translocation (2;3)(p22;q28) is associated with myeloid disorders. Cancer Genet Cytogenet. 79:1995;130-132.
Prigogina E.L., Fleischman E.W., Puchkova G.P., Mayakova S.A., Protasova A.K., Frenkel M.A. Chromosomes in acute nonlymphocytic leukemia. Hum Genet. 73:1986;137-146.
Levaltier X., Penther D., Bastard C., Troussard X. t(2;3)(p23;q26) in a patient with AML M2. Br J Haematol. 92:1996;1026-1029.
Whang-Peng J., Young R.C., Lee E.C., Longo D.L., Schechter G.P., DeVita V.T. Jr. Cytogenetic studies in patients with secondary leukemia/dysmyelopoietic syndrome after different treatment modalities. Blood. 71:1988;403-414.
Mecucci C., Vermaelen K., Tricot G., Louwagie A., Michaux J.-L., Bosly A., Thomas J., Barbieri D., Van Den Berghe H. 3q-, 3q+ anomaly in malignant proliferations in humans. Cancer Genet Cytogenet. 9:1983;367-381.
Yunis J.J., Rydell R.E., Oken M.M., Arnesen M.A., Mayer M.G., Lobell M. Refined chromosome analysis as an independent prognostic indicator in de novo myelodysplastic syndrome. Blood. 67:1986;1721-1730.
Bitter M.A., Neilly M.E., Le Beau M.M., Pearson M.G., Rowley J.D. Rearrangements of chromosome 3 involving bands 3q21 and 3q26 are associated with normal or elevated platelet counts in acute nonlymphocytic leukemia. Blood. 66:1985;1362-1370.
Kwong Y.L., Chan L.C., Lie K.W. t(2;3)(p13;q26) in a case of chronic myeloid leukemia. Cancer Genet Cytogenet. 59:1992;95-96.
Fleischman E.W., Volkova M.A., Frenkel M.A., Konstantinova L.N., Kulagina O.E., Baranov A.E., Gordeeva A.A. Translocation (2;3)(p13;q26) in two cases of myeloid malignancies. Cancer Genet Cytogenet. 87:1996;182-184.
Griggs A.P., Gascoyne R.D., Phillips G.L., Horsman D.E. Clinical, hematological and cytogenetic features in 24 patients with structural rearrangements of the q arm of chromosome 3. Br J Haematol. 83:1993;158-165.
Fonatsch C., Gudat H., Lengfelder E., Wandt H., Silling-Engelhardt G., Ludwig W.D., Thiel E., Freund M., Bodenstein H., Schwieder G., Gruneisen A., Aul C., Schnittger S., Rieder H., Haase D., Hild F. Correlation of cytogenetic findings with clinical features in 18 patients with inv(3)(q21q26) or t(3;3)(q21;q26). Leukemia. 8:1994;1318-1326.
Horsman D.E., Gascoyne R.D., Barnett M.J. Acute leukemia with structural rearrangements of chromosome 3. Leukemia and Lymphoma. 16:1995;369-377.
Kwong Y.L. Translocation (2;3) and myeloid disorders. Cancer Genet Cytogenet. 90:1996;93.
Secker-Walker L.M., Metha A., Bain B. Abnormalities of 3q21 and 3q26 in myeloid malignancy. a United Kingdom Cancer Cytogenetic Group study Br J Haematol. 91:1995;490-501.
This website uses cookies to improve user experience. Read more
Save & Close
Accept all
Decline all
Show detailsHide details
Cookie declaration
About cookies
Strictly necessary
Performance
Strictly necessary cookies allow core website functionality such as user login and account management. The website cannot be used properly without strictly necessary cookies.
This cookie is used by Cookie-Script.com service to remember visitor cookie consent preferences. It is necessary for Cookie-Script.com cookie banner to work properly.
Performance cookies are used to see how visitors use the website, eg. analytics cookies. Those cookies cannot be used to directly identify a certain visitor.
Used to store the attribution information, the referrer initially used to visit the website
Cookies are small text files that are placed on your computer by websites that you visit. Websites use cookies to help users navigate efficiently and perform certain functions. Cookies that are required for the website to operate properly are allowed to be set without your permission. All other cookies need to be approved before they can be set in the browser.
You can change your consent to cookie usage at any time on our Privacy Policy page.
