Monoolein-water liquid crystalline gels of gentamicin as bioresorbable implants for the local treatment of chronic osteomyelitis: in vitro characterization
Ouédraogo, M; Semdé, R; Somé, I.Tet al.
2008 • In Drug Development and Industrial Pharmacy, 34, p. 753-760
[en] To maximize the efficacy of chronic osteomyelitis antibiotherapy while reducing antibiotic systemic toxicity, as well as time and costs of hospitalizations, it has been thought that monoolein-water gels incorporating gentamicin sulfate could be used as local, bioresorbable,and sustained-release implants. For this purpose, four formulations were examined with regard to their physicochemical and in vitro drug release characteristics. Hot stage microscopy, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA),and X-ray diffraction showed cubic liquid crystalline and eutectic structures. The more suitable formulation consisting of 80-15-5%wt/wt monoolein-water-gentamicin sulfate progressively released the antibiotic for a period of 3 weeks without burst effect. Moreover, the content and the release profile of gentamicin sulfate were not significantly changed after storage at 2-6 degrees C for a period of 10 months.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Ouédraogo, M
Semdé, R
Somé, I.T
Traoré Ouédraogo, R
Guissou, I.P
Henschel, V
Dubois, J
Amighi, K
Evrard, Brigitte ; Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Language :
English
Title :
Monoolein-water liquid crystalline gels of gentamicin as bioresorbable implants for the local treatment of chronic osteomyelitis: in vitro characterization
Publication date :
2008
Journal title :
Drug Development and Industrial Pharmacy
ISSN :
0363-9045
eISSN :
1520-5762
Publisher :
Taylor & Francis, Philadelphia, United States - Pennsylvania
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