Antiviral Effect of Bacterially Produced Human Interferon (Hu-IFNα2) Against Experimental Vaccinia Infection in Calves

Animals; Antibodies, Viral; Cattle; DNA, Recombinant; Humans; Interferon Type I; Metabolic Clearance Rate; Vaccinia; Vaccinia virus; Viral Interference; Animalia; Bos taurus; Bovinae; Vesicular stomatitis virus

Abstract :

[en] The heterologous antiviral efficiency of bacterially produced human interferon (Hu-IFNα2) in the bovine species was studied, using vaccinia infection as experimental model. In a double blind experiment, young calves were intramuscularly injected daily for seven consecutive days with different doses of Hu-IFNα2 or placebo, the treatment starting 24 h before intradermal inoculation of vaccinia virus. A clear protection by interferon was observed in all the IFN treated animals, although individual variations in the sensitivity to IFN were recorded. The efficiency of treatment varied according to the dose of IFN used: With the highest dose (106 IU/kg), complete protection could be obtained. The only side-effect observed was hyperthermia. Circulating antiviral activity appeared quite early after each IFN injection, presented a more or less biphasic kinetics, and was completely cleared after 24 h, justifying the daily treatment schedule. The first evidence of an in vivo antiviral effect of human interferon in the bovine species opens broad perspectives for a future use of interferon in veterinary medicine. © 1985, Mary Ann Liebert, Inc. All rights reserved.

Disciplines :

Veterinary medicine & animal health

Author, co-author :

Werenne, J.; Free University of Brussels

Broecke, C. V.; Free University of Brussels

Schwers, Anne; Université de Liège - ULiège > Faculté de Médecine vétérinaire

Goossens, A.; Free University of Brussels

Bugyaki, L.; Institute of Hygiene and Epidemiology (IHE)

Maenhoudt, M.; Université de Liège - ULiège > Faculté de Médecine vétérinaire

Pastoret, Paul-Pierre ; Université de Liège - ULiège > Faculté de Médecine vétérinaire

Language :

English

Title :

Antiviral Effect of Bacterially Produced Human Interferon (Hu-IFNα2) Against Experimental Vaccinia Infection in Calves

Publication date :

1985

Journal title :

Journal of Interferon Research

ISSN :

0197-8357

Publisher :

Mary Ann Liebert, Inc., New York, United States - New York

Volume :

Issue :

Pages :

129-136

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://www.liebertpub.com/doi/pdf/10.1089/jir.1985.5.129

Available on ORBi :

since 21 May 2019

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Bibliography

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