Thermophysical Fingerprinting of Probiotic-Based Products

[en] Variability in efficacy and safety is a worldwide concern with commercial probiotics for their growing and inevitable use in food and health sectors. Here, we introduce a probiotic thermophysical fingerprinting methodology using a coupling thermogravimetry and differential scanning calorimetry. Qualitative and quantitative information on the material decomposition and transition phases is provided under heating conditions. By monitoring the changes in both mass and internal energy over temperature and time, a couple of thermal data at the maximum decomposition steps allow the creation of a unique and global product identity, depending on both strain and excipient components. We demonstrate that each powder formulation of monostrain and multistrain from different lots and origins have a unique thermophysical profile. Our approach also provides information on the formulation thermostability and additive/excipient composition. An original fingerprint form is proposed by converting the generated thermal data sequence into a star-like pattern for a perspective library construction.

Research center :

TERRA Teaching and Research Centre - TERRA

Disciplines :

Life sciences: Multidisciplinary, general & others

Author, co-author :

Razafindralambo, Hary ; Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > SMARTECH

Razafindralambo, Aurélie

Blecker, Christophe ; Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > SMARTECH

Language :

English

Title :

Thermophysical Fingerprinting of Probiotic-Based Products

Alternative titles :

[en] Belgique

Publication date :

10 July 2019

Journal title :

Scientific Reports

eISSN :

2045-2322

Publisher :

Nature Publishing Group, London, United Kingdom

Volume :

Issue :

10011

Pages :

1-8

Peer reviewed :

Peer Reviewed verified by ORBi

Name of the research project :

PHYSCHEMPROBIO

Funders :

ULiège - Université de Liège [BE]

Commentary :

Funding number FSR-F-GABT-16/2

Available on ORBi :

since 12 August 2019

Statistics

Number of views

75 (11 by ULiège)

Number of downloads

70 (4 by ULiège)

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Scopus citations^®

Scopus citations^®
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