Magnetic resonance enterography perfusion parameters reveal complex changes in affected and unaffected segments in Crohn's disease

VIEUJEAN, Sophie; COIBION, Caroline; SEIDEL, Laurence; LOUIS, Edouard; MEUNIER, Paul

doi:10.1080/00365521.2020.1802773

Article (Scientific journals)

Magnetic resonance enterography perfusion parameters reveal complex changes in affected and unaffected segments in Crohn's disease

VIEUJEAN, Sophie; COIBION, Caroline; SEIDEL, Laurence et al.

2020 • In Scandinavian Journal of Gastroenterology

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/257257

DOI
10.1080/00365521.2020.1802773

PubMed
32757858

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Keywords :

Crohn’s disease; control group; dynamic contrast-enhanced; magnetic resonance enterography; perfusion parameters

Abstract :

[en] Objectives: To compare dynamic contrast-enhanced (DCE)-MRI parameters in affected and unaffected segments of CD patients with those of a control group, and to assess the correlation between DCE-MRI parameters and clinical index of activity (HBI) as well as biomarkers (CRP and faecal calprotectin). Methods: We performed a single-center prospective study of CD patients and control subjects who underwent DCE-MRI. Regions of interest were drawn in segments and the program (Olea Medical - Canon) provided values for transfer constant (Ktrans), fractional volume of extravascular-extracellular space (Ve), slope of enhancement (SoE), time to maximum enhancement (TME), maximum enhancement (ME) and enhancement ratio (ER) which were determined and compared. Results: Fifteen CD patients (mean age 42 years; 10 women) and 7 healthy subjects (mean age 40.4 years; 6 women) were included. Paired comparisons of affected and unaffected segments in CD showed a significant increase of all parameters in affected segments, except for ER and TME. When comparing to controls, the affected segments did not show any significant difference, while a significant decrease in most of the parameters (except for ER and TME) was observed when comparing unaffected segments of CD patients to controls. In CD, significant correlations between DCE-MRI parameters and biomarkers (CRP, faecal calprotectin) were more frequent in unaffected segments than in affected segments. Conclusions: Significant differences in perfusion parameters were observed between affected and unaffected segments of CD patients and between unaffected segments and those of control subjects. This suggests complex perfusion changes in both unaffected and affected intestinal segments in CD.

Disciplines :

Gastroenterology & hepatology

Author, co-author :

VIEUJEAN, Sophie ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de gastroentérologie, hépatologie, onco. digestive

COIBION, Caroline; Centre Hospitalier Universitaire de Liège - CHU > Service médical de radiodiagnostic

SEIDEL, Laurence ; Centre Hospitalier Universitaire de Liège - CHU > Département de gestion des systèmes d'informations (GSI) > Secteur d'appui à la recherche clinique et biostatistique

LOUIS, Edouard ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de gastroentérologie, hépatologie, onco. digestive

MEUNIER, Paul ; Centre Hospitalier Universitaire de Liège - CHU > Département de Physique Médicale > Service médical de radiodiagnostic

Language :

English

Title :

Magnetic resonance enterography perfusion parameters reveal complex changes in affected and unaffected segments in Crohn's disease

Publication date :

06 August 2020

Journal title :

Scandinavian Journal of Gastroenterology

ISSN :

0036-5521

eISSN :

1502-7708

Publisher :

Taylor & Francis, United Kingdom

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 23 February 2021

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