Advisory Committees; Aged; Aged, 80 and over; Biomedical Research; Clinical Trials as Topic; Congresses as Topic; Frail Elderly; Humans; Osteoporosis/therapy; Frailty; ICOPE; osteoporosis; prevention
Abstract :
[en] Interactions among physiological pathways associated with osteoporosis and sarcopenia are thought to contribute to the onset of frailty. The International Conference on Frailty and Sarcopenia Research Task Force thus met in March 2020 to explore how emerging interventions to manage fracture and osteoporosis in older adults may reduce frailty, disability, morbidity, and mortality in the older population. Both pharmacological and non-pharmacological interventions (including nutritional intervention, exercise, and other lifestyle changes) were discussed, including nutritional intervention, exercise, and other lifestyle changes. Pharmacological treatments for osteoporosis include bone-forming and antiresorptive agents, which may optimally be used in sequential or combination regimens. Since similar mechanisms related to resorption underlie physiological changes in muscle and bone, these interventions may provide benefits beyond treating osteoporosis. Clinical trials to test these interventions, however, often exclude frail older persons because of comorbidities (such as mobility disability and cognitive impairment) or polypharmacy. The Task Force recommended that future clinical trials use harmonized protocols, including harmonized inclusion criteria and similar outcome measures; and that they test a range of multidomain therapies. They further advocated more high-quality research to develop interventions specifically for people who are frail and old. The ICOPE program recommended by WHO appears to be highly recommended to frail older adults with osteoporosis.
Disciplines :
General & internal medicine Public health, health care sciences & services
Author, co-author :
Rolland, Y.
Cesari, M.
Fielding, R. A.
Reginster, Jean-Yves ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Vellas, B.
Cruz-Jentoft, A. J.
Language :
English
Title :
Osteoporosis in Frail Older Adults: Recommendations for Research from the ICFSR Task Force 2020.
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