[en] Monocyclic β-lactams revive the research field on antibiotics, which are threatened by the emergence of resistant bacteria. A six-step synthetic route was developed, providing easy access to new 3-amino-1-carboxymethyl-4-phenyl-β-lactams, of which the penicillin-binding protein (PBP) inhibitory potency was demonstrated biochemically.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Decuyper, Lena; SynBioC Research Group, Department of Green Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000, Ghent, Belgium
Jukič, Marko; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000, Ljubljana, Slovenia
Sosič, Izidor; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000, Ljubljana, Slovenia
Amoroso, Ana Maria ; Université de Liège - ULiège > Département des sciences de la vie > Centre d'Ingénierie des Protéines (CIP)
Verlaine, Olivier ; Université de Liège - ULiège > Département des sciences de la vie > Centre d'Ingénierie des Protéines (CIP)
Joris, Bernard ; Université de Liège - ULiège > Integrative Biological Sciences (InBioS)
Gobec, Stanislav; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000, Ljubljana, Slovenia
D'hooghe, Matthias ; SynBioC Research Group, Department of Green Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000, Ghent, Belgium
Language :
English
Title :
Synthesis and Penicillin-binding Protein Inhibitory Assessment of Dipeptidic 4-Phenyl-β-lactams from α-Amino Acid-derived Imines.
Publication date :
02 January 2020
Journal title :
Chemistry: An Asian Journal
ISSN :
1861-4728
eISSN :
1861-471X
Publisher :
John Wiley and Sons Ltd, Chichester, West Sussex, Germany
The authors gratefully acknowledge the Research Foundation Flanders (FWO), the Slovenian Research Agency (research program P1-0208) and Belspo IAP-Project P44-iPros for financial support.
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