[en] Continuation of experience-dependent neural activity during offline sleep and wakefulness episodes is a critical component of memory consolidation. Using functional magnetic resonance imaging (fMRI), offline consolidation effects have been evidenced probing behavioural and neurophysiological changes during memory retrieval, i.e., in the context of task practice. Resting state fMRI (rsfMRI) further allows investigating the offline evolution of recently learned information without the confounds of online task-related effects. We used rsfMRI to investigate sleep-related changes in seed-based resting functional connectivity (FC) and amplitude of low frequency fluctuations (ALFF) after spatial navigation learning and relearning. On Day 1, offline resting state activity was measured immediately before and after topographical learning in a virtual town. On Day 4, it was measured again before and after relearning in an extended version of the town. Navigation-related activity was also recorded during target retrieval, i.e., online. Participants spent the first post-training night under regular sleep (RS) or sleep deprivation (SD) conditions. Results evidence FC and ALFF changes in task-related neural networks, indicating the continuation of navigation-related activity in the resting state. Although post-training sleep did not modulate behavioural performance, connectivity analyses evidenced increased FC after post-training SD between navigation-related brain structures during relearning in the extended environment. These results suggest that memory traces were less efficiently consolidated after post-learning SD, eventually resulting in the use of compensatory brain resources to link previously stored spatial elements with the newly presented information.
Disciplines :
Neurosciences & behavior
Author, co-author :
Deantoni, Michele ; Université de Liège - ULiège > GIGA ; Neuropsychology and Functional Neuroimaging Research Unit (UR2NF) at CRCN-Centre for Research in Cognition and Neurosciences and UNI-ULB Neurosciences Institute, Université Libre de Bruxelles (ULB), CP191 Av. F. Roosevelt 50, 1050 Bruxelles, Belgium
Villemonteix, Thomas; Neuropsychology and Functional Neuroimaging Research Unit (UR2NF) at CRCN-Centre for Research in Cognition and Neurosciences and UNI-ULB Neurosciences Institute, Université Libre de Bruxelles (ULB), CP191 Av. F. Roosevelt 50, 1050 Bruxelles, Belgium ; Psychopathology and Neuropsychology Lab, Paris 8 University, Rue de la Liberté 2, 93,526 Saint-Denis, France
Balteau, Evelyne ; Université de Liège - ULiège > Département des sciences de la vie > Virologie - Immunologie
Schmidt, Christina ; Université de Liège - ULiège > Département de Psychologie > Neuropsychologie
Peigneux, Philippe ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et revalidation cognitive ; Neuropsychology and Functional Neuroimaging Research Unit (UR2NF) at CRCN-Centre for Research in Cognition and Neurosciences and UNI-ULB Neurosciences Institute, Université Libre de Bruxelles (ULB), CP191 Av. F. Roosevelt 50, 1050 Bruxelles, Belgium
Language :
English
Title :
Post-Training Sleep Modulates Topographical Relearning-Dependent Resting State Activity.
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE] EOS - The Excellence Of Science Program [BE]
Funding text :
Funding: This research was funded by the Fonds de la Recherche Scientifique Médicale (FRSM grant #7020836, Brussels, Belgium) and the Excellence of Science (EOS) FNRS-FWO (MEMODYN grant #30446199). At the time of the study, TV was funded by an Université Libre de Bruxelles (ULB) Individual Fellowship. MD is supported by FRIA (Fonds pour la Recherche dans l’Industrie et l’Agriculture) Fellowship. CS is FNRS Research Associate. The APC was funded by EOS MEMODYN grant #30446199.This research was funded by the Fonds de la Recherche Scientifique M?dicale (FRSM grant #7020836, Brussels, Belgium) and the Excellence of Science (EOS) FNRS-FWO (MEMODYN grant #30446199). At the time of the study, TV was funded by an Universit? Libre de Bruxelles (ULB) Individual Fellowship. MD is supported by FRIA (Fonds pour la Recherche dans l?Industrie et l?Agriculture) Fellowship. CS is FNRS Research Associate. The APC was funded by EOS MEMODYN grant #30446199.
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