Humans; Human Papillomavirus Viruses; Prognosis; Tomography, X-Ray Computed/methods; Retrospective Studies; Papillomavirus Infections; Oropharyngeal Neoplasms; Anus Neoplasms/diagnostic imaging; Multidisciplinary
Abstract :
[en] The paper deals with the evaluation of the performance of an existing and previously validated CT based radiomic signature, developed in oropharyngeal cancer to predict human papillomavirus (HPV) status, in the context of anal cancer. For the validation in anal cancer, a dataset of 59 patients coming from two different centers was collected. The primary endpoint was HPV status according to p16 immunohistochemistry. Predefined statistical tests were performed to evaluate the performance of the model. The AUC obtained here in anal cancer is 0.68 [95% CI (0.32-1.00)] with F1 score of 0.78. This signature is TRIPOD level 4 (57%) with an RQS of 61%. This study provides proof of concept that this radiomic signature has the potential to identify a clinically relevant molecular phenotype (i.e., the HPV-ness) across multiple cancers and demonstrates potential for this radiomic signature as a CT imaging biomarker of p16 status.
Disciplines :
Radiology, nuclear medicine & imaging
Author, co-author :
Leijenaar, Ralph T H; Radiomics (Oncoradiomics SA), Liège, Belgium
Akshayaa Vaidyanathan; Radiomics (Oncoradiomics SA), Liège, Belgium ; The D-Lab, Department of Precision Medicine, GROW-School for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands
Guiot, Julien ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Lambin, Philippe; The D-Lab, Department of Precision Medicine, GROW-School for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands ; Department of Radiology and Nuclear Medicine, GROW-School for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands
Lovinfosse, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > > Service médical de médecine nucléaire et imagerie onco
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