[en] Cytokine storm is considered a driving factor of COVID-19 severity. However, the triggering and resolution of this cytokine production as well as the link
between this phenomenon and infected cells is still poorly understood. Considering that M1 macrophages are specialized for pathogen killing and secrete pro-inflammatory
cytokines as well as chemokines upon Ifn-γ activation, an assessment of their contributions in cytokine storms is necessary. Moreover, considering that Fc receptors for
immunoglobulin G (FcγR) expression was found to be stimulated by Ifn-γ in monocytes and macrophages and that FcγR markedly affect antigen uptake in macrophages,
exploring the potential link between FcγR-mediated antibody-dependent infections of M1 macrophages and the surge of cytokine storms caused by SARS-CoV-2 infections
constitutes a promising avenue of research to explain the phenomenon of antibody-dependent enhancement (ADE).
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Olivier, Thibaut ; Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH) > FARAH: Santé publique vétérinaire
Desmecht, Daniel ; Université de Liège - ULiège > Département de morphologie et pathologie (DMP) > Pathologie spéciale et autopsies
Language :
English
Title :
Antibody-dependent enhancement (ADE) in Covid-19 physiopathology, a cross-model single-cell RNA-seq perspective
Publication date :
23 September 2023
Event name :
10th European Meeting on Viral Zoonoses
Event place :
Saint-Raphaël, France
Event date :
23 - 26 September 2023
Audience :
International
Tags :
CÉCI : Consortium des Équipements de Calcul Intensif
