functional MRI; light; locus coeruleus; melanopsin; non-image-forming; transient pupil response; Cognitive Neuroscience; Behavioral Neuroscience; General Medicine
Abstract :
[en] Light has many non-image-forming functions including modulation of pupil size and stimulation of alertness and cognition. Part of these non-image-forming effects may be mediated by the brainstem locus coeruleus. The processing of sensory inputs can be associated with a transient pupil dilation that is likely driven in part by the phasic activity of the locus coeruleus. In the present study, we aimed to characterise the task-evoked pupil response associated with auditory inputs under different light levels and across two cognitive tasks. We continuously monitored the pupil of 20 young healthy participants (mean [SD] 24.05 [4.0] years; 14 women) whilst they completed an attentional and an emotional auditory task whilst exposed to repeated 30-40-s blocks of light interleaved with darkness periods. Blocks could either consist of monochromatic orange light (0.16 melanopic equivalent daylight illuminance (EDI) lux) or blue-enriched white light of three different levels [37, 92, 190 melanopic EDI lux; 6500 K]. For the analysis, 15 and then 14 participants were included in the attentional and emotional tasks, respectively. Generalised linear mixed models showed a significant main effect of light level on the task-evoked pupil responses triggered by the attentional and emotional tasks (p ≤ 0.0001). The impact of light was different for the target versus non-target stimulus of the attentional task but was not different for the emotional and neutral stimulus of the emotional task. There is a smaller sustained pupil size during brighter light blocks but, a higher light level triggers a stronger task-evoked pupil response to auditory stimulation, presumably through the recruitment of the locus coeruleus.
Disciplines :
Life sciences: Multidisciplinary, general & others
Beckers, Elise ; Université de Liège - ULiège > GIGA ; Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, The Netherlands
Sharifpour, Roya ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques
Berger, Alexandre ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology ; Institute of Neuroscience (IoNS), Université Catholique de Louvain (UCLouvain), Brussels, Belgium ; Synergia Medical SA, Mont-Saint-Guibert, Belgium
Paparella, Ilenia ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Aizpurua, Jose Fermin Balda; GIGA-Cyclotron Research Centre-In Vivo Imaging, University of Liège, Liège, Belgium
Koshmanova, Ekaterina ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques
ERDF - European Regional Development Fund [BE] Fonds Léon Fredericq [BE] Siemens [DE]
Funding text :
The authors thank Christine Bastin, Annick Claes, Fabienne Collette, Christian Degueldre, Catherine Hagelstein, Gregory Hammad, Brigitte Herbillon, Patrick Hawotte, Sophie Laloux, Erik Lambot, Benjamin Lauricella, Zoé Leysens, André Luxen, Christophe Phillips, Pierre Maquet, and Eric Salmon for their help over the different steps of the study. This study was supported by the Belgian Fonds National de la Recherche Scientifique (FNRS; CDR J.0222.20), the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska‐Curie grant agreement No 860613, the Fondation Léon Frédéricq, ULiège—U. Maastricht Imaging Valley, ULiège‐Valeo Innovation Chair ‘Health and Well‐Being in Transport’ and Sanfran (LIGHT‐CABIN), the European Regional Development Fund (Biomed‐Hub), and Siemens. None of these funding sources had any impact on the design of the study nor on the interpretation of the findings. Alexandre Berger is supported by Synergia Medial SA and the Walloon Region (Industrial Doctorate Programme, convention n°8193). Elise Beckers is supported by the Maastricht University—Liège University Imaging Valley. Roya Sharifpour and Jose Fermin Balda Aizpurua are supported by the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska‐Curie grant agreement No 860613. Islay Campbell, Ekaterina Koshmanova, Ilenia Paparella, Nasrin Mortazavi, Gilles Vandewalle are supported by the FRS‐FNRS. Siya Sherif was supported by ULiège‐Valeo Innovation Chair and Siemens Healthineers.
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