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Abstract :
[en] Besides its physiological role in thermoregulation, sweat is also known as a rich biofluid which contains a lot of constituents. Their appearance or change in their concentration may actually offer the opportunity to either diagnose or monitor in real time different pathologies or healthcare. Some of these biomarkers are already or are about to be used in this direction. Several data from the literature establish a causal relationship between muscle fatigue during sporting activity and the appearance of significant muscle damage.
In this perspective, we put forward the hypothesis that biomarkers could demonstrate the onset of critical muscle fatigue, whose appearance is measured using an appropriate device. To identify those potential biomarkers, sweat sampling tests were carried out on sedentary middle-age 20 years old male subjects, before and after unusual exercise (30’ running at 80% of VO2max speed). Protein content was analyzed by mass spectrometry. Our preliminary results show significant variations in certain analytes concentrations which could be linked to the existence of mechanisms related to the repair process of micro-injuries in muscles.
In a second step, the final determination of one or a combination of some determinant biomarkers of muscle fatigue would lead to the design of a biosensor which must give, by optical reading, a fatigue level.
