The Cochlear Matrisome: Importance in Hearing and Deafness.

[en] The extracellular matrix (ECM) consists in a complex meshwork of collagens, glycoproteins, and proteoglycans, which serves a scaffolding function and provides viscoelastic properties to the tissues. ECM acts as a biomechanical support, and actively participates in cell signaling to induce tissular changes in response to environmental forces and soluble cues. Given the remarkable complexity of the inner ear architecture, its exquisite structure-function relationship, and the importance of vibration-induced stimulation of its sensory cells, ECM is instrumental to hearing. Many factors of the matrisome are involved in cochlea development, function and maintenance, as evidenced by the variety of ECM proteins associated with hereditary deafness. This review describes the structural and functional ECM components in the auditory organ and how they are modulated over time and following injury.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Pressé, Mary ; Université de Liège - ULiège > GIGA > GIGA Neurosciences - Developmental Neurobiology

Malgrange, Brigitte ; Université de Liège - ULiège > Département des sciences cliniques > Neurologie

Delacroix, Laurence ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques

Language :

English

Title :

The Cochlear Matrisome: Importance in Hearing and Deafness.

Publication date :

07 December 2023

Journal title :

Matrix Biology: Journal of the International Society for Matrix Biology

ISSN :

0945-053X

eISSN :

1569-1802

Publisher :

Elsevier B.V., Netherlands

Volume :

125

Pages :

40 - 58

Peer reviewed :

Peer reviewed

Additional URL :

https://api.elsevier.com/content/article/PII:S0945053X23001257?httpAccept=text/xml

Funding text :

This work was supported by grants from the Belgian National Funds for Scientifc Research (FRS-FNRS, Belgium), the Fondation Léon Fredericq, and the Fonds spéciaux (ULiège, Belgium).

Available on ORBi :

since 30 January 2024

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