A Scoping Review on the Use of Non-invasive Brain Stimulation Techniques for persistent Post-concussive Symptoms

[en] Background: in the context of managing persistent post-concussive symptoms (PPCS), existing treatments like pharmacotherapy, cognitive behavioral therapy, and physical rehabilitation show only moderate effectiveness. The emergence of neuromodulation techniques in PPCS management has led to debates regarding optimal stimulation parameters and their overall efficacy. Methods: this scoping review involved a comprehensive search of PubMed and ScienceDirect databases, focusing on controlled studies examining the therapeutic potential of non-invasive brain stimulation (NIBS) techniques in adults with PPCS. Results: among 940 abstracts screened, only 5 studies, encompassing 103 patients (12 to 29 per study) met the inclusion criteria. These studies assessed the efficacy of transcranial direct current stimulation (tDCS) or repetitive transcranial magnetic stimulation (rTMS) applied to specific brain regions (i.e., left dorsolateral pre-frontal cortex (DLPFC) or left motor cortex (M1)) for addressing cognitive, psychological symptoms, headaches, and general PPCS. Results indicated improvements in cognitive functions with tDCS. In contrast, reductions in headache intensity and depression scores were observed with rTMS, while no significant findings were noted for general symptoms with rTMS. Conclusion: although these pilot studies suggest promise for rTMS and tDCS in PPCS management, further research with larger-scale investigations and standardized protocols is imperative to enhance treatment outcomes for PPCS patients.

Disciplines :

Neurology

Author, co-author :

Khosravi, Mohammadhossein ; Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group ; Centre du Cerveau², University Hospital of Liège, Liège, Belgium

Louras, Mélanie ; Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group ; Centre du Cerveau², University Hospital of Liège, Liège, Belgium

Martens, Géraldine ; Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group ; Sport & Trauma Applied Research Lab, University of Montréal, Montréal QC, Canada

Kaux, Jean-François ; Université de Liège - ULiège > Département des Sciences de l'activité physique et de la réadaptation > Médecine physique, réadaptation et traumatologie du sport ; Centre Hospitalier Universitaire de Liège - CHU > > Service de médecine de l'appareil locomoteur

Lejeune, Nicolas ^✱; Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group ; CHN William Lennox, Ottignies, Belgium ; Institute of NeuroScience, UCLouvain, Brussels, Belgium

Thibaut, Aurore ^✱; Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group ; Centre du Cerveau², University Hospital of Liège, Liège, Belgium

^✱ These authors have contributed equally to this work.

Language :

English

Title :

A Scoping Review on the Use of Non-invasive Brain Stimulation Techniques for persistent Post-concussive Symptoms

Publication date :

17 February 2024

Journal title :

Biomedicines

eISSN :

2227-9059

Special issue title :

Neuromodulation from Theory to Therapy

Volume :

Volume II

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 12 February 2024

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