[en] When solutions of ipratropium and clenbuterol were atomised at 300 kPa and 450 kPa in equipment suitable for the inhalation of drugs by calves, the numbers, velocities and diameters of the particles produced were similar. When the pressure was increased to 600 kPa more of the particles were less than 2 microns in diameter and fewer were more than 7 microns in diameter, the fractions of the total mass of the solution generated in these size ranges were similarly increased and decreased, and the velocities of the particles were increased. At any given pressure, the numbers of particles of different sizes, and the proportions of the total mass generated, were similar for the solutions of ipratropium and clenbuterol, but a solution of saline produced more particles with a diameter less than 3 microns. Particles from the solution of ipratropium had the highest velocity and particles from the solution of clenbuterol had the lowest velocity.
Disciplines :
Veterinary medicine & animal health Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Genicot, Bruno; Université de Liège - ULiège > Faculté de médecine vétérinaire, physiologie
Lapp, K.; Institute of Mathematical Statistics, University of Tartu, Estonia
Close, Roland; Université de Liège - ULiège > Faculté de médecine vétérinaire, physiologie
Lindsey, J. K.; Université de Liège - ULiège > Faculty of Economics
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Bibliography
Agresti (1990) Multinomial response model. Categorical Data Analysis , A Agresti, John Wiley & Sons, New York; 306-346.
Atkins, Barker, Mathisen (1992) The design and development of inhalation drug delivery systems. Pharmaceutical Inhalation Aerosol Technology , A.J Hickey, Marcel Dekker, New York; 155-185.
Bachalo, Hess, Hartwell (1980) An instrument for spray droplet size and velocity measurements. Journal of Engineering Power 102:798-806.
Bachalo, Houser (1984) Development of the phase/doppler spray analyzer for liquid drop size and velocity characterizations. Proceedings of the 20th Joint Propulsion Conference , USA, June 11 to 13, 1984; 1-13.
Brain, Valberg, Sneddon (1985) Mechanisms of aerosol deposition and clearance. Aerosols in Medicine Principles, Diagnosis and Therapy , F Moren, M.T Newhouse, M.B Dolovich, Elsevier, Amsterdam; 123-147.
Genicot, Close, Mouligneau, Lekeux (1992) Clinical and pulmonary function changes induced by aerosol-therapy during bovine acute respiratory distress syndrome. Proceedings of the XVII World Buiatrics Congress, August 31 to September 4, 1992 (USA) 3:236-241.
Genicot, Mouligneau, Close, Lekeux (1994) Functional effects of a muscarinic receptor blockade during acute respiratory distress syndrome in double-muscled calves. Veterinary Record 134:110-113.
Genicot, Peckova, Close, Lindsey, Lambert, Lekeux (1994) Technical study of some major parameters influencing the performances of an aerosol delivery equipment suitable for calves. Veterinary Research 25:468-477.
Gonda (1992) Targeting by deposition. Pharmaceutical Inhalation Aerosol Technology , A.J Hickey, Marcel Dekker, New York; 61-82.
Gross (1988) Ipratropium bromide. New England Journal of Medicine 319:484-494.
Gustin, Bakima, Art, Lekeux, Lomba (1988) Pulmonary function values and growth in Belgian white and blue double-muscled cattle. Research in Veterinary Science 45:405-410.
Keck, Krüger, Noll, Machleidt (1972) Synthesen von neuen Amino-Halogen-substituierten Phenyl-aminoathanoleum. Arzneimittel Forschung (Drug Research) 22:861-869.
Lekeux, Hajer, Breukink (1984) Effect of somatic growth on pulmonary function values in healthy Friesian cattle. American Journal of Veterinary Research 45:2003-2007.
Moren (1985) Aerosol dosage forms and formulations. Aerosols in Medicine. Principles, Diagnosis and Therapy , F Moren, M.T Newhouse, M.B Dolovich, Elsevier, Amsterdam; 261-287.
Newman, Pavia, Clarke (1981) Improving the bronchial deposition of pressurized aerosols. Chest 80:909-911.
Newman, Pellow, Clarke (1987) In vitro comparison of De Vilbiss Jet and Ultrasonic Nebulizers. Chest 92:991-994.
Payne (1989) Inhaled aerosols: clinical and experimental applications in relation to asthma. Asthma Reviews , J Morley, Academic Press, London; 1-26.
Reilly, Rae (1954) Other physical measurements: surface tension (Section 5). Physico-Chemical Methods , 5th edn., Methuen, London; 1:629-659.
Schulz, Banholzer, Pook (1976) Eine neue Methode zur technischen Darstellung von tertiaren and quartären d,1-Tropasäureestem emiger N-substituierter Nortropan- bzw. Granatan-3-ole. Arzneimittel Forschung (Drug Research) 26:960-974.
Stahl (1967) Scaling of respiratory variables in mammals. Journal of Applied Physiology 22:453-460.
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